Preferred Label : Cantrixil;
NCIt synonyms : cis-4-(para-hydroxyphenyl)-7,4'-dihydroxy-3',5'-dimethoxy-8-methylisoflavan;
NCIt related terms : TRX-E-002-1;
NCIt definition : A cyclodextrin-encapsulated, third generation super-benzopyran (SBP) compound with
potential antineoplastic activity. Upon intraperitoneal (IP) administration, cantrixil
enhances the activation and expression of c-Jun, downregulates phosphorylated extracellular
signal-regulated kinase (p-ERK) and induces activation of caspase-3, -7 and -9, thereby
inducing tumor cell apoptosis. c-Jun, an activator protein-1 (AP-1) transcription
factor component, is involved in a wide range of cellular processes including cell
cycle progression, differentiation, cell transformation and apoptosis.;
UNII : 5DVS457HEG;
InChIKey : JFVVPUGGRUGRBJ-AVRDEDQJSA-N;
CAS number : 1803036-93-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1803036-93-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : TRX-E-002-1; TRX E 002 1;
NCI Metathesaurus CUI : CL951687;
Origin ID : C159719;
UMLS CUI : C4507380;
Currated CISMeF NLP mapping
- Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
