NCIt definition : A topically bioavailable small molecule inhibitor of serine/threonine-protein kinase
B-raf (BRAF) protein with potential chemoprotective activity. Upon topical administration,
BRAF inhibitor LUT014 targets and binds BRAF and, through the paradoxical effect of
BRAF inhibition, induces mitogen-activated protein kinase (MAPK) signaling, which
leads to the proliferation and migration of healthy human keratinocytes. This decreases
dermal toxicities associated with epidermal growth factor (EGFR) inhibitor therapy.
BRAF, a member of the raf family of serine/threonine protein kinases, plays a role
in the regulation of MAPK/extracellular signal-regulated kinase (ERK) signaling pathways.;
Semantic type(s)