Preferred Label : Anti-GITR Agonistic Monoclonal Antibody ASP1951;
NCIt synonyms : Anti-GITR Agonistic Monoclonal Antibody PTZ-522;
NCIt related terms : ASP-1951;
NCIt definition : A human, high-affinity, tetravalent monospecific agonistic monoclonal antibody targeting
glucocorticoid-induced tumor necrosis factor receptor (GITR; tumor necrosis factor
superfamily member 18; TNFRSF18; CD357), with potential immune checkpoint modulating
activity. Upon administration, anti-GITR agonistic monoclonal antibody ASP1951 binds
to and activates GITR, which is expressed on the cell surface of multiple types of
T-lymphocytes. This induces both the activation and proliferation of tumor antigen-specific
T-effector cells (Teffs), and suppresses the function of activated T-regulatory cells
(Tregs), which may promote the elimination of tumor cells. GITR, a member of the TNF
receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface
of multiple immune cell types, including Tregs, Teffs, B-cells, and natural killer
(NK) cells. Inappropriately activated Tregs suppress both Teffs and T-cell receptor
(TCR) signaling.;
UNII : F6WFM86G7J;
Molecule name : PTZ-522; ASP-1951; ASP 1951; PTZ 522;
NCI Metathesaurus CUI : CL951269;
Origin ID : C159411;
UMLS CUI : C5204409;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
