Anthracycline Antineoplastic Antibiotic

Preferred Label : Anthracycline Antineoplastic Antibiotic;

NCIt synonyms : Chemotherapy, Cancer, Anthracyclines; Anthracyclines; Anthracycline Antibiotic;

NCIt related terms : anthracycline;

NCIt definition : An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.;

Alternative definition : NCI-GLOSS: A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.;

ChEBI ID : CHEBI:49322;

Codes from synonyms : CDR0000044916;

Details

Origin ID

C1594;

UMLS CUI

C0003234;

Currated CISMeF NLP mapping
- Anthracycline (substance) [SNOMED CT concept]
- anthracyclines [MeSH Descriptor]
- anthracyclines [MeSH concept]
- anthracyclines and related substances [ATC Code]
See also inter- (CISMeF)
- Medicinal product containing anthracycline and acting as antineoplastic agent (product) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Anthracycline (substance) [SNOMED CT concept]
- Medicinal product containing anthracycline and acting as antineoplastic agent (product) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]

Keyword's position in hierarchy(ies) :

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