Preferred Label : Indium In 111-FPI-1547;
NCIt synonyms : [111In]-FPI-1547; Indium In 111-FPI-1397-FPI-1175; Indium In 111-labeled FPI-1547;
NCIt definition : A radioimmunoconjugate composed of FPI-1175 (AVE1642), a humanized monoclonal antibody
against insulin-like growth factor-1 receptor (IGF-1R) linked, via the bifunctional
chelate FPI-1397, to the radioisotope indium-111 (111In or In-111), with potential
imaging activity upon single photon emission computed tomography (SPECT). Upon administration
of indium In 111-FPI-1547, the FPI-1547 moiety targets and binds to IGF-1R expressed
on tumor cells. Upon uptake and imaging, IGF-1R-expressing tumor cells can be visualized.
This allows assessment of IGF-1R expression on tumor cells as well as tumor uptake
of the agent. The linker promotes increased clearance of the radioisotope.;
NCI Metathesaurus CUI : CL950888;
Origin ID : C158816;
UMLS CUI : C5203991;
Semantic type(s)
- concept_is_in_subset
- has_target
