Preferred Label : Lutetium Lu 177-NeoB;
NCIt synonyms : [177Lu]-NeoB; 177Lu-NeoB; Lutetium Lu 177 DOTA-NeoBOMB1; Lutetium 177-NeoB;
NCIt definition : A radioconjugate consisting of the gastrin-releasing peptide receptor (GRPR) antagonist,
NeoB, linked via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting
radioisotope lutetium Lu 177, with potential antineoplastic activity. Upon administration,
lutetium Lu 177 NeoB targets and binds to GRPRs present on certain tumor cells. Upon
binding and internalization, this radioconjugate specifically delivers a cytotoxic
dose of beta radiation to GRPR-expressing cells. GRPR, also known as bombesin receptor
subtype 2, is a G protein-coupled receptor that is overexpressed in some cancer types.;
NCI Metathesaurus CUI : CL950703;
Origin ID : C158734;
UMLS CUI : C5203921;
Semantic type(s)
- concept_is_in_subset
- has_target
