GSTT2 wt Allele

Preferred Label : GSTT2 wt Allele;

NCIt synonyms : Glutathione S-Transferase Theta 2 (Gene/Pseudogene) wt Allele; Glutathione S-Transferase, Theta-2 Gene;

NCIt definition : Human GSTT2 wild-type allele is located in the vicinity of 22q11.23 and is approximately 4 kb in length. This allele, which encodes glutathione S-transferase theta-2 protein, plays a role in glutathione metabolism.;

NCIt note : The GSTT2 gene is a pseudogene in some populations. Lower expression of the GSTT2 gene may play a role in the occurrence of esophageal adenocarcinoma. (Gastroenterology, in press. https://doi.org/10.1053/j.gastro.2018.12.004.);

NCI Metathesaurus CUI : CL937863;

GenBank Accession Number : L38503;

Details

Origin ID

C158389;

UMLS CUI

C4761733;

OMIM relation
- Glutathione s-transferase, theta-2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 22q11.23 [NCIt concept]
gene_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Glutathione Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
gene_plays_role_in_process
- Detoxification [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients