Preferred Label : Empagliflozin;
NCIt synonyms : 1-Chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene;
NCIt definition : An orally available competitive inhibitor of sodium-glucose co-transporter 2 (SGLT2;
SLC5A2) with antihyperglycemic activity. Upon oral administration, empagliflozin selectively
and potently inhibits SGLT2 in the kidneys, thereby suppressing the reabsorption of
glucose in the proximal tubule. Inhibition of SGLT2 increases urinary glucose excretion
by the kidneys, resulting in a reduction of plasma glucose levels in an insulin-independent
manner. Inhibition of SGLT2 in the kidneys also suppresses the renal reabsorption
of 1,5-anhydroglucitol (1,5AG). This lowers serum 1,5AG and neutrophil 1,5-anhydroglucitol-6-phosphate
(1,5AG6P) levels, which may improve neutropenia and neutrophil dysfunction in patients
with glycogen storage disease type Ib (GSD Ib). SGLT2, a transport protein exclusively
expressed in the proximal renal tubules, mediates approximately 90% of renal glucose
reabsorption from tubular fluid.;
UNII : HDC1R2M35U;
InChIKey : OBWASQILIWPZMG-QZMOQZSNSA-N;
CAS number : 864070-44-0;
Drug name : Jardiance;
Molecule name : BI 10773; BI-10773;
NCI Metathesaurus CUI : CL937668;
Origin ID : C158136;
UMLS CUI : C3490348;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
