Preferred Label : Dihydroorotate Dehydrogenase Inhibitor AG-636;
NCIt synonyms : DHODH Inhibitor AG-636;
NCIt definition : An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential
antineoplastic activity. Upon administration, AG-636 specifically targets, binds to
and prevents the activation of DHODH, thereby preventing the fourth enzymatic step
in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation,
DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species
(ROS) formation, enables differentiation and induces apoptosis in susceptible tumor
cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO)
to orotate in the endogenous synthesis of UMP.;
Molecule name : AG-636; AG 636;
NCI Metathesaurus CUI : CL937737;
Origin ID : C158103;
UMLS CUI : C4764051;
Semantic type(s)
- concept_is_in_subset
- has_target
