Preferred Label : Abacavir/Dolutegravir/Lamivudine;
NCIt synonyms : ABC/DTG/3TC;
NCIt definition : A fixed combination of abacavir sulfate, a nucleoside reverse transcriptase inhibitor
(NRTI) analog of guanosine; dolutegravir, an integrase strand-transfer inhibitor (INSTI);
and lamivudine, an NRTI analog of cytidine, that may be used to treat human immunodeficiency
virus (HIV) infection. Upon oral administration, abacavir and lamivudine are phosphorylated
into active metabolites that inhibit the HIV reverse transcriptase (RT) enzyme competitively
and act as a chain terminator of DNA synthesis. This interferes with the generation
of DNA copies of viral RNA, which is necessary for the synthesis of new virions. Dolutegravir
binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of
viral genetic material into human chromosomes. This prevents integrase from binding
to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which
is essential for the HIV replication cycle. This further prevents HIV-1 replication.;
Drug name : Triumeq;
Origin ID : C157543;
UMLS CUI : C3854896;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
TIVICAY, TRIUMEQ and JULUCA (dolutegravir containing medicines) – Possible Risk of
Neural Tube Defects
Destinataires : Professionnels de la santé, y compris spécialistes des maladies infectieuses,
spécialistes du virus de l’immunodéficience humaine (VIH) et infirmiers(ères), virologues
cliniques, obstétriciens(ennes), gynécologues, pédiatres, spécialistes de la santé
sexuelle, pharmaciens(ennes) et omnipraticiens(ennes).
https://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2018/66998a-fra.php
2018
false
false
false
Canada
French
English
pharmacovigilance note
neural tube defects
pregnancy
dolutegravir
dolutegravir
HIV integrase inhibitors
hiv infections
abnormalities, drug-induced
guidelines for drug use
pregnancy trimester, first
infant, newborn
administration, oral
drug combinations
lamivudine, abacavir and dolutegravir
dolutegravir and rilpivirine
heterocyclic compounds, 3-ring
dolutegravir, rilpivirine drug combination
Abacavir/Dolutegravir/Lamivudine
Rilpivirine
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