Preferred Label : Xinmailong;
NCIt synonyms : XML;
NCIt definition : A Chinese medicine composed of bioactive composite extracted from Periplaneta americana
consisting of adenosine, inosine, protocatechuic acid, and pyroglutamate dipeptides,
with potential cardioprotective activity. Upon administration, xinmailong may inhibit
the phosphorylation of mitogen-activated protein kinase 3/extracellular signal-regulated
kinase 1 (MAPK3/ERK1), mitogen-activated protein kinase 1 (MAPK1)/ERK2, AKT, and glycogen
synthase kinase-3 beta (GSK3-beta), thereby decreasing the expression of transcription
factor GATA-4. GATA-4 is a key regulator of cardiac hypertrophy, mediating gene expressions
in response to heart failure (HF) stimuli by activating a variety of HF-associated
genes, such as atrial natriuretic factor (ANF), B-type natriuretic peptide (BNP),
and beta-myosin heavy chain (beta-MHC). Decreased expression of GATA-4 may limit the
transcription of these genes and offer protection against certain types of HF.;
NCI Metathesaurus CUI : CL937068;
Origin ID : C157492;
UMLS CUI : C4506833;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
