NCIt definition : A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the negative
immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, pimivalimab targets, binds to and inhibits PD-1 and its downstream
signaling pathways. This may restore immune function through the activation of T-cells
and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune
checkpoint that negatively regulates T-cell activation and effector function when
activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it
plays an important role in tumor evasion from host immunity.;
UNII : MA05AF40UO;
CAS number : 2293951-22-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2293951-22-9
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G-SRS /a ;
Semantic type(s)