Preferred Label : Poliglusam;
NCIt synonyms : Deacetylchitin; Chitosan;
NCIt definition : A naturally occurring polysaccharide composed of beta-1,4-linked glucosamine residues
with potential antineoplastic activity. Upon administration, poliglusam may, through
a not yet fully elucidated mechanism, reduce advanced glycation end product (AGE)
levels. This may reduce the interaction between AGEs and the receptor for advanced
glycation end products (RAGE, AGER), which is overexpressed in some tumor types and
is associated with poor patient outcomes. AGE-RAGE interaction may induce the phosphorylation
and subsequent degradation of retinoblastoma protein (Rb), a key cell cycle inhibitor
and tumor suppressor, through the phosphoinositide 3-kinase (PI3K)/protein kinase
B (PKB, Akt) signaling pathway. Hyperphosphorylation of Rb leads to the dissociation
of the Rb-E2F complex, which triggers the activation of genes required for G1/S transition
and tumorigenesis. Reducing AGE levels may limit AGE-RAGE interaction and normalize
the G1 to S-phase transition, potentially reducing the development and progression
of certain cancers. AGEs are non-enzymatic protein modifications produced during the
normal aging process that have been shown to play a role in the development and progression
of some cancers.;
UNII : 82LKS4QV2Y;
CAS number : 9012-76-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 9012-76-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Origin ID : C157372;
UMLS CUI : C3473981;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
https://www.has-sante.fr/jcms/p_3470378/fr/reaxon-direct
2023
France
health technology assessment
chitosan
Murine Peripheral Nerves
peripheral nerves
Sectioning
peripheral neurorrhaphy
Tube Dosing Unit
Manager
leadership
Suture Device
emigration and immigration
Peripheral Nerve
Destination
Poliglusam
Packaging Tube
Square Mile
tube, nos
transection of peripheral nerve, nos
Suture
guideline
Suture Dosage Form
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