NCIt related terms : Anti-TIM-3 Monoclonal Antibody BGB-A425;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the inhibitory
T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3;
TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration, surzebiclimab binds
to TIM-3 expressed on certain T-cells, including tumor-infiltrating lymphocytes (TILs),
thereby preventing the engagement of TIM-3 by its ligands, phosphatidylserine (PtdSer)
and galectin-9. This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes
and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction
in tumor cell proliferation. TIM-3, a transmembrane protein and immune checkpoint
receptor, is associated with tumor-mediated immune suppression.;
Semantic type(s)