NCIt synonyms : Anti-S15 mAb NC318; Anti-Siglec-15 Monoclonal Antibody NC318;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting sialic acid binding
Ig-like lectin 15 (Siglec-15; SIGLEC15; S15), a member of the sialic acid-binding
immunoglobulin type lectins, with potential antineoplastic and immunomodulatory activities.
Upon administration, anti-S15 monoclonal antibody NC318 targets and binds to S15 on
the surface of tumor-associated macrophages (TAMs) and certain tumor cells. Binding
to S15 may disrupt TAM-mediated activities such as promotion of tumor initiation and
metastasis of tumor cells, inhibition of T-cell responses, and stimulation of tumor
angiogenesis and disease progression. S15, a highly conserved type 1 cell surface
protein, normally involved in osteoclast differentiation and bone remodeling, may
play a role in the survival and differentiation of TAMs.;
Semantic type(s)