GDP-L-Fucose Synthase

Preferred Label : GDP-L-Fucose Synthase;

NCIt synonyms : Short-Chain Dehydrogenase/Reductase Family 4E Member 1; Tissue-Specific Transplantation Antigen 3; Protein FX; GDP-4-Keto-6-Deoxy-D-Mannose Epimerase-Reductase; EC 1.1.1.271; Testis Tissue Sperm-Binding Protein Li 45a; Red Cell NADP(H)-Binding Protein; GDP-4-Keto-6-Deoxy-D-Mannose-3,5-Epimerase-4-Reductase; Tissue Specific Transplantation Antigen 3; Tissue Specific Transplantation Antigen P35B; GDP-Keto-6-Deoxymannose-3,5-Epimerase, 4-Reductase; TSTA3; 3-5 Epimerase/4-Reductase; GFUS;

NCIt definition : GDP-L-fucose synthase (321 aa, 36 kDa) is encoded by the human GFUS gene. This protein is involved in the NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-L-fucose.;

NCIt note : Peptides derived from GDP-L-fucose synthase may act as T-cell-specific autoantigens in multiple sclerosis in HLA-DRB3*02:02 positive subjects. (Science Translational Medicine. 2018: doi:10.1126/scitranslmed.aat430);

NCI Metathesaurus CUI : CL936059;

Details

Origin ID

C156969;

UMLS CUI

C4722633;

Automatic exact mappings (from CISMeF team)
- GDP-L-fucose synthase [HGNC gene]
- Gdp-L-fucose synthase [OMIM gene]
OMIM relation
- Gdp-L-fucose synthase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GFUS Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Exosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amino and Nucleotide Sugars Metabolism Pathway [NCIt concept]
- Fructose and Mannose Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Carbohydrate Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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