Preferred Label : Farudodstat;
NCIt synonyms : DHODH Inhibitor ASLAN003; Dihydroorotate Dehydrogenase Inhibitor ASLAN003;
NCIt definition : An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential
antineoplastic activity. Upon administration, farudodstat specifically targets, binds
to and prevents the activation of DHODH, thereby preventing the fourth enzymatic step
in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation,
DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species
(ROS) formation, enables differentiation and induces apoptosis in susceptible tumor
cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO)
to orotate in the endogenous synthesis of UMP.;
UNII : I58WE41H6X;
CAS number : 1035688-66-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1035688-66-4
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G-SRS /a ;
Molecule name : ASLAN 003; ASLAN-003;
NCI Metathesaurus CUI : CL935809;
Origin ID : C156777;
UMLS CUI : C5667175;
Semantic type(s)
- concept_is_in_subset
- has_target
