Preferred Label : PRMT1 Inhibitor GSK3368715;
NCIt synonyms : Protein Arginine Methyltransferase 1 Inhibitor GSK3368715;
NCIt definition : An orally available inhibitor of protein arginine N-methyltransferase 1 (PRMT1; Histone-arginine
N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4) with potential antineoplastic
activity. Upon administration, GSK3368715 inhibits monomethylation and asymmetric
dimethylation of arginine-bearing substrates, including histones, estrogen receptors,
RNA-binding proteins, and numerous non-histone substrates catalyzed by PRMT1. This
may inhibit tumor cell proliferation, migration, and invasion that is potentially
driven by PRMT1 overexpression or dysregulation. PRMT1-mediated methylation plays
a key role in the modulation of protein function, gene expression and cellular signaling.
Dysregulation and overexpression of PRMT1 has been associated with a number of solid
and hematopoietic cancers.;
Molecule name : GSK 3368715; GSK-3368715;
NCI Metathesaurus CUI : CL935878;
Origin ID : C156759;
UMLS CUI : C4745049;
Semantic type(s)
- concept_is_in_subset
- has_target
