NCIt definition : A humanized, immunoglobulin G4 (IgG4) monoclonal antibody directed against the negative
immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, nofazinlimab targets, binds to and inhibits PD-1 and its downstream
signaling pathways. This may restore immune function through the activation of T-cells
and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein
in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune
checkpoint that negatively regulates T-cell activation and effector function when
activated by its ligands programmed cell death-1 ligand 1 (PD-L1) and 2 (PD-L2); it
plays an important role in tumor evasion from host immunity.;