Brigimadlin - CISMeF

Preferred Label : Brigimadlin;

NCIt synonyms : BI907828; MDM2 Inhibitor BI 907828;

NCIt definition : An orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors.;

UNII : 9A934ZAN94;

CAS number : 2095116-40-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2095116-40-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BI 907828; BI-907828;

NCI Metathesaurus CUI : CL935863;

Details

Origin ID

C156709;

UMLS CUI

C4745006;

Automatic exact mappings (from CISMeF team)
- BI-907828 [MeSH concept]
- BI-907828 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BI-907828 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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