NCIt synonyms : Anti-hFcgammaRIIB mAb BI-1206; Anti-hFcgRIIB Monoclonal Antibody BI-1206;
NCIt related terms : BI-1206;
NCIt definition : A fully human monoclonal antibody targeting the Fc gamma receptor IIB (FcgRIIB; CD32B)
with potential immunomodulatory and antineoplastic activities. Upon intravenous administration,
anti-CD32B monoclonal antibody BI-1206 selectively binds to CD32B, a receptor expressed
on the surface of B-cells. This prevents CD32B-mediated internalization of anti-CD20
monoclonal antibodies, such as rituximab, which abrogates tumor cell resistance caused
by CD32B-mediated monoclonal antibody internalization and degradation of CD32B-expressing
B-cells. By blocking CD32B, BI-1206 may recover and enhance the activity of rituximab
and other anti CD20 monoclonal antibodies. In addition, BI-1206 itself activates the
immune system to exert an immune-mediated tumor cell death of B-cells. CD32B, an inhibitory
member of the FcgammaR family, is implicated in immune cell desensitization and tumor
cell resistance.;
Semantic type(s)