NCIt definition : A human immunoglobulin G4 (IgG4) monoclonal antibody directed against neuropilin-1
(NRP1; CD304; BDCA-4), with potential immunomodulatory and antineoplastic activities.
Upon administration, anti-NRP1 antibody ASP1948 specifically targets and binds to
NRP1. This prevents the binding of NRP1 to its ligand and may block the immune inhibitory
actions of regulatory T-cells (Tregs) mediated by the interaction of NRP1 with its
ligand. This may enhance the immune response against tumor cells. NRP1 is a transmembrane
co-receptor protein expressed in Tregs; it plays an important role in maintaining
the stability and function of Tregs.;
UNII : 857Y17E6U4;
Molecule name : ASP 1948; ASP-1948; PTZ329; PTZ 329;
Semantic type(s)