" /> Anti-LAG-3 Monoclonal Antibody Sym022 - CISMeF





Preferred Label : Anti-LAG-3 Monoclonal Antibody Sym022;

NCIt related terms : SYM-022;

NCIt definition : A recombinant, human Fc-inert monoclonal antibody targeting lymphocyte-activation gene 3 protein (LAG-3; LAG3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, monoclonal antibody Sym022 binds to human LAG-3 and blocks the interaction between LAG-3 and major histocompatibility complex class II (MHCII) molecules on the surface of antigen-presenting cells (APCs) and tumor cells. This prevents the negative regulation of T-cell activity that occurs via LAG-3-MHCII binding and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Additionally, Sym022 decreases LAG-3 surface levels through internalization and shredding. LAG-3 plays a key role in the activation of T-cells and natural killer (NK) cells.;

UNII : 7TQ52FVC2L;

CAS number : 2250088-52-7;

Molecule name : Sym 022; Sym-022;

NCI Metathesaurus CUI : CL563029;

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07/05/2025


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