" /> Orelabrutinib - CISMeF





Preferred Label : Orelabrutinib;

NCIt synonyms : BTK Inhibitor ICP-022;

NCIt definition : A small molecule inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase) with potential antineoplastic activity. Upon administration, orelabrutinib binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes.;

UNII : WJA5UO9E10;

InChIKey : MZPVEMOYADUARK-UHFFFAOYSA-N;

CAS number : 1655504-04-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1655504-04-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ICP 022; ICP-022;

NCI Metathesaurus CUI : CL563002;

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15/05/2024


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