Preferred Label : Batiraxcept;
NCIt synonyms : AXL Fc Fusion Protein AVB-S6-500; Anti-AXL Fusion Protein AVB-S6-500; RUGA-S6;
NCIt definition : A soluble fusion protein comprised of the extracellular domain of the receptor tyrosine
kinase (RTK) AXL (UFO) fused to a human immunoglobulin G1 (IgG1) Fc domain, with potential
antineoplastic activity. Upon administration, batiraxcept selectively binds to growth
arrest-specific protein 6 (GAS6), the endogenous ligand for AXL. This may inhibit
GAS6/AXL-mediated signaling, which plays a key role in tumor cell proliferation, survival,
invasion and metastasis, as well as immune evasion and resistance to other anticancer
agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of RTKs, is overexpressed
by many tumor cell types and its expression is associated with drug resistance and
poor prognosis.;
UNII : B6840JH4EB;
CAS number : 2268717-61-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2268717-61-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : AVB S6 500; AVB-S6-500; AVB-500;
NCI Metathesaurus CUI : CL562760;
Origin ID : C156017;
UMLS CUI : C5446331;
Semantic type(s)
- concept_is_in_subset
- has_target
