Brequinar - CISMeF

Preferred Label : Brequinar;

NCIt synonyms : Bipenquinate; 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid;

NCIt definition : A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04);

UNII : 5XL19F49H6;

InChIKey : PHEZJEYUWHETKO-UHFFFAOYSA-N;

CAS number : 96187-53-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 96187-53-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C23H15F2NO2;

Details

Origin ID

C1560;

UMLS CUI

C0280509;

Currated CISMeF NLP mapping
- brequinar [MeSH concept]
- brequinar [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- brequinar [MeSH concept]
- brequinar [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Brequinar Sodium [NCIt concept]
is_component_of_chemotherapy_regimen
- Brequinar/Fluorouracil [NCIt concept]
is_free_acid_or_base_form_of
- Brequinar Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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