Brequinar Sodium

Preferred Label : Brequinar Sodium;

NCIt synonyms : Sodium 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate;

NCIt definition : The sodium salt form of Brequinar. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04);

UNII : 49EEF6HRUS;

InChIKey : PZOHOALJQOFNTB-UHFFFAOYSA-M;

CAS number : 96201-88-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 96201-88-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : DUP-785;

Chemical formula : C23H14F2NO2.Na;

NSC code : 368390;

Codes from synonyms : NSC0368390;

Details

Origin ID

C1078;

UMLS CUI

C0877869;

Automatic exact mappings (from CISMeF team)
- brequinar [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- brequinar sodium [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- brequinar sodium [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_free_acid_or_base_form
- Brequinar [NCIt concept]
is_salt_form_of
- Brequinar [NCIt concept]

Keyword's position in hierarchy(ies) :

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