Preferred Label : NLRP3 Agonist BMS-986299;
NCIt synonyms : NLR Family Pyrin Domain Containing 3 Agonist BMS-986299;
NCIt related terms : BMS-986299;
NCIt definition : A nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing
3 (NLRP3; NACHT, LRR and PYD Containing Protein 3; NALP3) agonist with potential immunomodulatory
and antineoplastic activities. Upon administration, NLRP3 agonist BMS-986299 binds
to and activates NLRP3, potentially promoting NLRP3 inflammasome-mediated secretion
of interleukin-8 (IL-8), which may induce tumoricidal activity of natural killer (NK)
cells against tumor cells. NLRP3, a sensor component of the NLRP3 inflammasome plays
a significant role in immunity and inflammation, and may protect against tumorigenesis
in some cancers.;
UNII : VS58MO4P47;
CAS number : 2242952-69-6;
Molecule name : BMS-986299; BMS 986299;
NCI Metathesaurus CUI : CL562818;
Origin ID : C155945;
UMLS CUI : C4733672;
Semantic type(s)
- concept_is_in_subset
- has_target
