Mps1 Inhibitor BOS172722

Preferred Label : Mps1 Inhibitor BOS172722;

NCIt synonyms : Monopolar Spindle 1 Inhibitor BOS172722; TTK Inhibitor BOS172722;

NCIt definition : An orally bioavailable, selective inhibitor of the serine/threonine-protein kinase monopolar spindle 1 (Mps1; TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BOS172722 binds to and inhibits the activity of Mps1, a core component of the spindle assembly checkpoint (SAC). Inhibition of Mps1 activity compromises spindle assembly checkpoint, increases chromosome missegregation errors and decreases cancer cell viability. Mps1, a dual-specificity protein kinase expressed in proliferating normal tissues and aberrantly overexpressed in certain tumor types, is activated during mitosis and is essential in proper SAC function and chromosomal alignment.;

Molecule name : BOS 172722; BOS172722;

NCI Metathesaurus CUI : CL562779;

Details

Origin ID

C155895;

UMLS CUI

C4733646;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BOS172722 [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Dual Specificity Protein Kinase TTK [NCIt concept]

Keyword's position in hierarchy(ies) :

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