" /> Tegavivint - CISMeF





Preferred Label : Tegavivint;

NCIt synonyms : 9,10-Anthracenedione, 2,7-bis(((3R,5S)-3,5-dimethyl-1-piperidinyl)sulfonyl)-, 9,10-dioxime, rel-; Tegatrabetan;

NCIt definition : A small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity. Upon intravenous administration, tegavivint binds to transducin beta-like protein 1 (TBL1) and disrupts the binding of beta-catenin to TBL1. This promotes beta-catenin degradation, attenuates nuclear and cytoplasmic levels of beta-catenin, and reduces transcriptional activity of transcription factor 4 (TCF4) and expression of its target genes, cyclin D1, c-Myc and survivin. The Wnt/beta-catenin signaling pathway regulates cell morphology, motility, and proliferation; aberrant regulation of this pathway leads to neoplastic proliferation. Beta-catenin is frequently mutated in various tumors.;

UNII : 18AP231HUP;

InChIKey : GAPRVZKWPDRAJA-QOPKLXIQSA-N;

CAS number : 1227637-23-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1227637-23-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BC-2059; BC 2059;

NCI Metathesaurus CUI : CL562695;

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Keyword's position in hierarchy(ies) : arborescence

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11/05/2024


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