NCIt definition : A monoclonal antibody directed against the negative immunoregulatory human cell receptor
programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration, penpulimab targets,
binds to and inhibits PD-1 and its downstream signaling pathways. This may restore
immune function through the activation of T-cells and T-cell-mediated immune responses
against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily
(IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates
T-cell activation and effector function when activated by its ligands programmed cell
death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion
from host immunity.;