" /> ERK 1/2 Inhibitor ASTX029 - CISMeF





Preferred Label : ERK 1/2 Inhibitor ASTX029;

NCIt synonyms : Extracellular Signal-regulated Kinase Inhibitor ASTX029; Extracellular Signal-regulated Kinase 1/2 Inhibitor ASTX029; ERK Inhibitor ASTX029;

NCIt related terms : ASTX-029;

NCIt definition : An orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon administration, ASTX029 specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells.;

UNII : 14FDK6ISC9;

CAS number : 2095719-92-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2095719-92-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ASTX 029; ASTX-029;

NCI Metathesaurus CUI : CL556263;

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12/05/2024


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