NCIt definition : The anhydrous form of beroterkib, an orally bioavailable inhibitor of the extracellular
signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon
administration, beroterkib specifically binds to and inhibits both ERK 1 and 2, thereby
preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated
signal transduction pathways. This results in the inhibition of ERK-dependent tumor
cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety
of tumor cell types and plays a key role in the proliferation, differentiation and
survival of tumor cells.;
Semantic type(s)