Preferred Label : Near Infrared Imaging Agent HS-196;
NCIt synonyms : NIR-tethered Hsp90 Inhibitor HS-196; HSP90 Inhibitor-linked NIR Probe HS-196;
NCIt definition : An imaging agent containing a human heat shock protein 90 (Hsp90) inhibitor connected
by a linker to a near infrared (NIR) fluorescent dye. Upon intravenous administration,
HS-196 selectively and competitively binds to Hsp90 in cells. As Hsp90 is upregulated
in a variety of tumor cells, the accumulation of the NIR-tethered imaging agent allows
for in vivo detection due to enhanced uptake of HS-196. Hsp90 is a molecular chaperone
that plays a key role in the conformational maturation, stability and function of
oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL and mutated p53,
as well as many other molecules that are important in cell cycle regulation and/or
immune responses.;
Molecule name : HS 196; HS-196;
NCI Metathesaurus CUI : CL555224;
Origin ID : C154332;
UMLS CUI : C4727585;
Semantic type(s)
- concept_is_in_subset
- has_target
