" /> Near Infrared Imaging Agent HS-196 - CISMeF





Preferred Label : Near Infrared Imaging Agent HS-196;

NCIt synonyms : NIR-tethered Hsp90 Inhibitor HS-196; HSP90 Inhibitor-linked NIR Probe HS-196;

NCIt definition : An imaging agent containing a human heat shock protein 90 (Hsp90) inhibitor connected by a linker to a near infrared (NIR) fluorescent dye. Upon intravenous administration, HS-196 selectively and competitively binds to Hsp90 in cells. As Hsp90 is upregulated in a variety of tumor cells, the accumulation of the NIR-tethered imaging agent allows for in vivo detection due to enhanced uptake of HS-196. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.;

Molecule name : HS 196; HS-196;

NCI Metathesaurus CUI : CL555224;

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24/05/2025


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