Sotorasib - CISMeF

Preferred Label : Sotorasib;

NCIt definition : An orally available inhibitor of the specific KRAS mutation, p.G12C, with potential antineoplastic activity. Upon oral administration, sotorasib selectively targets, binds to and inhibits the activity of the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells. The KRAS p.G12C mutation is seen in some tumor cell types and plays a key role in tumor cell proliferation.;

UNII : 2B2VM6UC8G;

InChIKey : NXQKSXLFSAEQCZ-SFHVURJKSA-N;

CAS number : 2296729-00-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2296729-00-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Lumakras; Lumykras;

Molecule name : AMG 510; AMG-510;

NCI Metathesaurus CUI : CL555284;

Codes from synonyms : 59461;

Details

Origin ID

C154287;

UMLS CUI

C5418250;

Automatic exact mappings (from CISMeF team)
- sotorasib [ATC Code]
Currated CISMeF NLP mapping
- Sotorasib (substance) [SNOMED CT concept]
- sotorasib [MeSH concept]
- sotorasib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sotorasib (medicinal product) [SNOMED CT concept]
- Sotorasib (substance) [SNOMED CT concept]
- sotorasib [MeSH Supplementary Concept]
- sotorasib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- KRAS NP_004976.2:p.G12C [NCIt concept]
is_component_of_chemotherapy_regimen
- Sotorasib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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