Preferred Label : Phosphorylated-FAK Y397;
NCIt synonyms : Phosphorylated FAK Y397; Phospho-PTK2 (Y397); FAK (Phospho Y397); FAK (pY397); Phospho-PTK2 (Tyr397); Phosphorylated-Focal Adhesion Kinase 1 Y397; FAK (Phospho Tyr397); Focal Adhesion Kinase 1 Y397 Phosphorylated; Phospho-FAK (Y397);
NCIt definition : A post-translationally modified form of focal adhesion kinase 1 (FAK; FAK1; PTK2)
where the tyrosine (Y; Tyr) at residue 397 is phosphorylated. Cell adhesion-signaling
promotes the association of FAK with Src family kinases, which stimulates autophosphorylation
of FAK Y397 and creates a SH2-binding site on FAK to promote Src family kinase- and
integrin-mediated signaling.;
NCI Metathesaurus CUI : CL554927;
Origin ID : C153558;
UMLS CUI : C4727351;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
