Preferred Label : Triamcinolone Acetonide Transdermal System SUN-131;
NCIt synonyms : SUN-131 TDS; Triamcinolone Acetonide Transdermal Patch SUN-131;
NCIt definition : A transdermal system (TDS) containing triamcinolone acetonide, a synthetic glucocorticoid
with anti-inflammatory and immunomodulating properties. Upon application of the TDS
to the eyelid, triamcinolone acetonide binds to intracellular glucocorticoid receptors,
ultimately inducing the expression of glucocorticoid-responsive genes and lipocortins.
Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic
acid from membrane phospholipids and preventing the synthesis of prostaglandins and
leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine
production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic
T-lymphocytes is also inhibited. Triamcinolone acetonide also decreases the number
of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis
through increasing Ikappa-B expression and curtailing activation of nuclear factor
(NF)kappa-B.;
Molecule name : SUN-131; SUN 131;
NCI Metathesaurus CUI : CL554862;
Origin ID : C153426;
UMLS CUI : C4727247;
Semantic type(s)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
