Preferred Label : Phosphorylated EIF4E;
NCIt synonyms : Phosphorylated Eukaryotic Initiation Factor 4E; Phospho-EIF4E;
NCIt definition : A post-translationally modified form of eukaryotic translation initiation factor 4E
where either the threonine at residue 22 or the serine at residue 209 are phosphorylated.
Phosphorylation of eukaryotic translation initiation factor 4E increases its binding
to 7-methylguanosine-containing mRNA caps and may promote the translation of mRNAs
involved in epithelial mesenchymal transition (EMT), tumorigenesis and metastasis.;
NCI Metathesaurus CUI : CL554828;
Origin ID : C153382;
UMLS CUI : C4727212;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
