Preferred Label : CBP/beta-catenin Modulator E7386;
NCIt related terms : E-7386;
NCIt definition : An orally bioavailable, specific inhibitor of the canonical Wnt/beta-catenin signaling
pathway, with potential antineoplastic activity. Upon oral administration, CBP/beta-catenin
modulator E7386 inhibits beta-catenin and prevents the interaction of beta-catenin
with its transcriptional coactivator, CREB (cAMP response element-binding) binding
protein (CBP). This prevents binding of beta-catenin/CBP to WRE (Wnt-responsive element),
and inhibits the activation of transcription of a wide range of target genes of Wnt/beta-catenin
signaling, thereby preventing gene expression of many Wnt-related, pro-survival proteins
and suppressing tumor cell growth. The Wnt/beta-catenin signaling pathway regulates
cell morphology, motility, and proliferation; aberrant regulation of this pathway
leads to neoplastic proliferation. Beta-catenin is frequently mutated in various tumors.;
UNII : I0DX1FG55Y;
CAS number : 1799824-08-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1799824-08-0
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G-SRS /a ;
Molecule name : E 7386; E-7386;
NCI Metathesaurus CUI : CL554532;
Origin ID : C153376;
UMLS CUI : C4727208;
Semantic type(s)
- UMLS correspondences (same concept)
- E-7386 [MeSH Supplementary Concept]
- concept_is_in_subset
