Preferred Label : MAT2A Inhibitor AG-270;
NCIt related terms : AG-270;
NCIt definition : An orally available small molecule inhibitor of methionine adenosyltransferase II
alpha (MAT2A) with potential antineoplastic activity. Upon administration, AG-270
inhibits the activity of MAT2A, a metabolic enzyme responsible for the production
of S-Adenosyl-L-methionine (SAM), a primary donor of methyl groups in cellular transmethylation
reactions that regulate gene expression, cell growth, and differentiation. MAT2A activity
is selectively essential in cancer cells deficient in methylthioadenosine phosphorylase
(MTAP), a critical enzyme in the methionine salvage pathway, that is deleted in some
human cancers. Inhibition of MAT2A may potentially inhibit tumor cell growth in MTAP-deleted
cancers that rely heavily on SAM synthesis.;
UNII : E1P2TDU69L;
CAS number : 2201056-66-6;
Molecule name : AG 270; AG-270;
NCI Metathesaurus CUI : CL554312;
Origin ID : C153180;
UMLS CUI : C4727076;
Semantic type(s)
- concept_is_in_subset
- has_target
