NCIt definition : A recombinant, humanized monoclonal antibody directed against the negative immunoregulatory
human cell surface receptor, programmed cell death 1 (PD-1), with potential immune
checkpoint inhibitory and antineoplastic activities. Upon intravenous administration,
lipustobart binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands, programmed
cell death-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation
of PD-1 and its downstream signaling pathways, leading to the activation of both T-cells
and T-cell-mediated immune responses against tumor cells. PD-1 is a transmembrane
protein in the immunoglobulin (Ig) superfamily expressed on activated T-cells that
negatively regulates T-cell activation and effector function when activated by its
ligands. PD-1 plays an important role in tumor evasion from host immunity.;
Semantic type(s)