Preferred Label : Orludodstat;
NCIt synonyms : DHODH Inhibitor BAY2402234; Dihydroorotate Dehydrogenase Inhibitor BAY2402234;
NCIt definition : An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential
antineoplastic activity. Upon administration, orludodstat specifically targets, binds
to and prevents the activation of DHODH, thereby preventing the fourth enzymatic step
in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation,
DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species
(ROS) production, enables differentiation and induces apoptosis in susceptible tumor
cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO)
to orotate in the endogenous synthesis of UMP.;
UNII : X8GF945GMK;
CAS number : 2225819-06-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2225819-06-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : BAY-2402234; BAY 2402234;
NCI Metathesaurus CUI : CL554394;
Origin ID : C153137;
UMLS CUI : C5544270;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
