Preferred Label : Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso;
NCIt synonyms : Bispecific NY-ESO-1- and LAGE-1A-specific TCR/Anti-CD3; HLA- A*0201-Restricted NY-ESO-1- and LAGE-1A-specific Soluble TCR/Anti-CD3 Bispecific
Molecule;
NCIt related terms : IMCNYESO;
NCIt definition : A bispecific molecule composed of a soluble, affinity-enhanced T-cell receptor (TCR)
specific for human leukocyte antigen A2 (HLA-A2)-restricted cancer-testis antigens
(CTAs) NY-ESO-1 and L antigen family member 1 isoform A (LAGE-1A; LAGE-A1; CT6.2a),
fused to a single-chain variable fragment (scFv) specific for the T-cell surface antigen
CD3, with potential immunomodulating and antineoplastic activities. Upon infusion,
anti-NY-ESO1/LAGE-1A TCR/scFv anti-CD3 IMCnyeso specifically targets and binds with
its TCR moiety to NY-ESO-1 and/or LAGE-1A expressed on tumor cells and with its scFv
moiety to CD3 expressed on T-cells. This crosslinks tumor cells and T-cells, re-directs
and activates T-cells, and results in a cytotoxic T-lymphocyte (CTL)-mediated destruction
of NY-ESO-1 and/or LAGE-1A-positive tumor cells. NY-ESO-1 and LAGE-1A, members of
the cancer-testis antigen (CTA) family, are overexpressed on the surface of various
tumor cell types; they share a specific HLA-A*0201 epitope, 157-165, which is expressed
on certain tumor cell types while its expression is not found on normal, healthy cells.;
UNII : C416JC9CX0;
Molecule name : IMCnyeso;
NCI Metathesaurus CUI : CL554387;
Origin ID : C153130;
UMLS CUI : C4727044;
Semantic type(s)
- concept_is_in_subset
- has_target
