NCIt definition : A bispecific, human monoclonal antibody with potential antineoplastic activity. REGN4018
contains two antigen-recognition sites: one for human CD3, a T cell surface antigen
that is part of the T cell receptor complex, and one for human mucin 16 (MUC16, cancer
antigen 125; CA125; FLJ14303), a member of the mucin family of glycoproteins that
is overexpressed by several epithelial cancers, including ovarian cancer. Upon administration,
ubamatamab binds to both T-cells and MUC16-expressing tumor cells, which cross-links
the T-cells to the tumor cells, and may result in a potent cytotoxic T-lymphocyte
(CTL) response against the MUC16-expressing tumor cells.;
Semantic type(s)