Hsp90 Inhibitor LAM-003

Preferred Label : Hsp90 Inhibitor LAM-003;

NCIt synonyms : LAM-003A Prodrug LAM-003; Prodrug LAM-003;

NCIt definition : An L-alanine ester prodrug of LAM-003A, an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon oral administration, LAM-003 is converted to LAM-003A. LAM-003A selectively targets and binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may inhibit the growth and survival of a wide variety of cancer cell types. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability, and degradation of many oncogenic signaling proteins.;

Molecule name : LAM-003; LAM 003;

NCI Metathesaurus CUI : CL554182;

Details

Origin ID

C152979;

UMLS CUI

C4726995;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]

Keyword's position in hierarchy(ies) :

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