" /> Umbralisib Tosylate - CISMeF





Preferred Label : Umbralisib Tosylate;

NCIt definition : The tosylate form of umbralisib, an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. umbralisib inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.;

UNII : FU8XW5V3FS;

CAS number : 1532533-72-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1532533-72-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Ukoniq;

NCI Metathesaurus CUI : CL554127;

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12/05/2024


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