" /> Umbralisib Tosylate - CISMeF





Preferred Label : Umbralisib Tosylate;

NCIt definition : The tosylate form of umbralisib, an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. umbralisib inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.;

UNII : FU8XW5V3FS;

CAS number : 1532533-72-4;

Drug name : Ukoniq;

NCI Metathesaurus CUI : CL554127;

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07/05/2025


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