NCIt definition : An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic
subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic
activity. PI3K-delta inhibitor TGR-1202 inhibits PI3K and prevents the activation
of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces
cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is
expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted
inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells.
PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor
cell regulation and survival.;