" /> Umbralisib - CISMeF





Preferred Label : Umbralisib;

NCIt synonyms : 2-((1S)-1-(4-Amino-3-(3-fluoro-4-(1-methylethoxy)phenyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one;

NCIt definition : An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. PI3K-delta inhibitor TGR-1202 inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.;

UNII : 38073MQB2A;

InChIKey : IUVCFHHAEHNCFT-INIZCTEOSA-N;

CAS number : 1532533-67-7;

Molecule name : RP-5264; TGR-1202; TGR 1202;

NCI Metathesaurus CUI : CL445680;

Codes from synonyms : 59505;

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31/05/2025


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