Losoxantrone - CISMeF

Preferred Label : Losoxantrone;

NCIt synonyms : Biantrazole;

NCIt related terms : CI-941;

NCIt definition : An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin.;

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antipyrazoles.;

UNII : 47KPH00809;

InChIKey : YROQEQPFUCPDCP-UHFFFAOYSA-N;

CAS number : 88303-60-0;

Molecule name : DuP 941; CI-941;

Chemical formula : C22H27N5O4;

Codes from synonyms : CDR0000045401; NSC0357885;

Details

Origin ID

C1521;

UMLS CUI

C0245032;

Currated CISMeF NLP mapping
- biantrazole [MeSH concept]
- losoxantrone [MeSH concept]
- losoxantrone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- losoxantrone [MeSH concept]
- losoxantrone [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Losoxantrone Hydrochloride [NCIt concept]
is_component_of_chemotherapy_regimen
- Cyclophosphamide/Losoxantrone [NCIt concept]
- Doxorubicin/Losoxantrone [NCIt concept]
- Filgrastim/Losoxantrone/Paclitaxel [NCIt concept]
is_free_acid_or_base_form_of
- Losoxantrone Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients