Preferred Label : STAT3 Inhibitor DSP-0337;
NCIt synonyms : Napabucasin Prodrug DSP-0337; Cancer Stemness Inhibitor DSP-0337;
NCIt definition : An orally administered prodrug of napabucasin, a small molecule cancer stemness inhibitor
with potential antineoplastic activity. Upon administration, DSP-0337 is converted
to its active form, napabucasin. Napabucasin targets and inhibits signal transducer
and activator of transcription 3 (STAT3), thereby preventing STAT-3-mediated signaling.
The STAT3 pathway is overly active in many cancer types and is implicated in cancer
stem cell-mediated growth, recurrence and resistance to conventional chemotherapies.;
Molecule name : DSP 0337; DSP-0337;
NCI Metathesaurus CUI : CL553215;
Origin ID : C151994;
UMLS CUI : C4726608;
Semantic type(s)
- concept_is_in_subset
- has_target
