NCIt definition : A study that compares two groups of people: those with the disease or condition under
study (cases) and a very similar group of people who do not have the disease or condition
(controls). Researchers study the medical and lifestyle histories of the people in
each group to learn what factors may be associated with the disease or condition.
For example, one group may have been exposed to a particular substance that the other
was not. Also called retrospective study.;
Alternative definition : CDISC: A study that compares groups of people with generally similar characteristics,
those with the condition under study (case) and those without the condition under
study (control).; CDISC-GLOSS: Retrospective study in which individuals with an outcome (cases) are
compared with those who do not have the outcome (controls). The outcome variable (disease,
event, experience, biomarker) is chosen first, and the exposure (e.g., treatment)
is evaluated in cases vs controls to see whether there is an association between exposure
and outcome. [After AMA Manual of Style] See also outcome, observational study, exposure.;
Currated CISMeF NLP mapping