" /> Vonoprazan Fumarate - CISMeF





Preferred Label : Vonoprazan Fumarate;

NCIt synonyms : 1H-Pyrrole-3-methanamine, 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, (2E)-2-Butenedioate (1:1); Voquezna;

NCIt definition : The fumarate salt form of vonoprazan, a pyrrole derivative and reversible potassium-competitive acid blocker (P-CAB), with potential antacid activity. Upon administration, vonoprazan specifically and competitively binds to the gastric hydrogen-potassium ATPase (H /K ATPase) proton pump at or, more likely, near its potassium ion (K ) binding site and sterically inhibits K binding. This blocks the activation of the H /K ATPase by K , inhibits the proton pump and prevents gastric acid secretion, thereby lowering gastric acid levels.;

UNII : 4QW3X4AMLB;

CAS number : 881681-01-2;

Drug name : Takecab;

Molecule name : TAK-438;

NCI Metathesaurus CUI : CL553177;

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09/05/2025


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